The Role of Mitochondria in Alzheimer’s Disease and its Potential Therapies
Open Access
- 31 December 2020
- journal article
- Published by Abasyn University in Abasyn Journal of Life Sciences
- p. 175-183
- https://doi.org/10.34091/ajls.3.2.17
Abstract
Alzheimer’s disease (AD) is a common form of dementia, affecting millions of people worldwide, mostly the elderly population. The gradual decline in cognitive functions, loss of memory, and sleep disorder are the most frequently reported in AD patients. Multiple studies have been carried out to find a potential therapeutic approach to prevent the progression of Alzheimer’s disease and increase the performance of cognitive abilities. Mitochondrial dysfunction leading to oxidative stress and other environmental factors, diet and lifestyle are the major risk factors. Mitochondria play an essential role and are a potential therapeutic target for treating and preventing AD progression. Various biochemical molecules involved in mitochondrial metabolic pathways are tested as directly acting on mitochondria. Numerous antioxidants are considered as a potential treatment for AD. Here, we highlighted the emerging mitochondrial base therapies and potent antioxidants that can be used in Alzheimer’s disease treatments.Keywords
This publication has 41 references indexed in Scilit:
- Evaluating risk of dementia in older people: a pathway to personalized prevention?European Heart Journal, 2020
- Molecular Basis of Familial and Sporadic Alzheimer's DiseaseCurrent Alzheimer Research, 2016
- Alzheimer's diseaseThe Lancet, 2016
- A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differencesJournal of the Formosan Medical Association, 2016
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease PathogenesisBiological Psychiatry, 2014
- Review Article: Genetics of Alzheimer DiseaseJournal of Geriatric Psychiatry and Neurology, 2010
- Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Amyloid Precursor Protein Trafficking, Processing, and FunctionOnline Journal of Public Health Informatics, 2008
- Prevalence of Dementia in the United States: The Aging, Demographics, and Memory StudyNeuroepidemiology, 2007
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991