Synthesis and Application of Iron Oxide Nanoparticles in Bone Tissue Repair
Open Access
- 15 September 2021
- journal article
- review article
- Published by Hindawi Limited in Journal of Nanomaterials
- Vol. 2021, 1-14
- https://doi.org/10.1155/2021/3762490
Abstract
Nanoparticles play a vital role in bone tissue repair engineering, especially iron oxide nanoparticles (IONPs), which have magnetic properties, semiconductor properties, and nontoxicity at the same time, and their applications in biomedicine have received widespread attention. This review summarizes the excellent performance of IONPs in enhancing scaffold functions, promoting stem cell differentiation, and labeling positioning, in order to understand the research progress and future development trends of IONPs in bone tissue repair engineering, as well as the security issues. Firstly, IONPs can affect the expression of genes and proteins to accelerate the process of biomineralization under a magnetic field. Then, the composite of IONPs and polymers can synthesize a scaffold which can promote the attachment, proliferation, and bone differentiation of stem cells. Furthermore, IONPs can also mark the location of drugs in the body to follow up the process of bone repair. Therefore, extensive research on the manufacturing and application range of IONPs is of great significance to bone tissue repair engineering.Keywords
Funding Information
- Beijing Municipal Natural Science Foundation (L202006, 11972065)
This publication has 148 references indexed in Scilit:
- Chitosan nanoparticles: Preparation, size evolution and stabilityInternational Journal of Pharmaceutics, 2013
- Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivoScientific Reports, 2013
- Electrochemical synthesis of magnetic iron oxide nanoparticles with controlled sizeJournal of Nanoparticle Research, 2011
- Mimicking natural bio-mineralization processes: A new tool for osteochondral scaffold developmentTrends in Biotechnology, 2011
- Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and TherapyAccounts of Chemical Research, 2011
- Evaluation of iron oxide nanoparticle biocompatibilityInternational Journal of Nanomedicine, 2011
- Active scaffolds for on-demand drug and cell deliveryProceedings of the National Academy of Sciences of the United States of America, 2010
- A study on synthesis and properties of Fe3O4 nanoparticles by solvothermal methodGlass Physics and Chemistry, 2010
- Cell Uptake and in Vitro Toxicity of Magnetic Nanoparticles Suitable for Drug DeliveryMolecular Pharmaceutics, 2009
- A Magnetism-Assisted Chemical Vapor Deposition Method To Produce Branched or Iron-Encapsulated Carbon NanotubesJournal of the American Chemical Society, 2007