It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
Open Access
- 24 November 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 19 (11), e3001448
- https://doi.org/10.1371/journal.pbio.3001448
Abstract
Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.Funding Information
- Fundação para a Ciência e a Tecnologia (UIDB/04539/2020)
- Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-28541)
- Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-029452)
- European Regional Development Fund (CENTRO-01-0145-FEDER-000008:BrainHealth2020)
- “la Caixa” Foundation/FCT, IP (LCF/PR/HP20/52300003)
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