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COMPARISON THE EFFECT OF ECHIUM AMOENUM EXTRACT WITH FLUOXETINE ON DEPRESSION IN MENOPAUSAL WOMEN. A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL

Parisa Yousefee Baghbadoranee, H N K Al-Salman, Manish Vyas, K. Venkateshwarlu, A. Mohammadi, Oksana Strus, Mansour Amraei, A.E. Dorofeev, Galina Eduardovna Brkich, Behzad Fouladi Dehaghi,
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Published: 1 July 2019

Abstract: Aim: A semisolid (avaleha) herbal formulation Drakshavaleha (DKV) was prepared based on the method described in Ayurvedic Formulary of India. It contains Vitis vinifera (Draksha), Piper longum (Pippali), Glycyrrhiza glabra (Yeshtimadhu), Zingiber officinale (Sunthi), Bambusa arundinacea (Vamshalochana), Emblica officinalis (Dhatri Phala or Amalaki), and honey and sugar (Sarkara). Materials and Methods: Methanolic extract of the DKV formulations was used for this study. Methanolic extract of three marketed preparation of DKV also use for the comparative study of DKV. This formulation was known as DKV-1, DKV-2, and DKV-3. A sample of this marketed formulation also used for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Result and Discussion: The methanolic extract of DKV exhibited a maximum DPPH scavenging activity of 68.24% at 100 μg/ml, and marketed formulations of DKV (DKV-1, DKV-2, and DKV-3) exhibited maximum DPPH scavenging activity 67.90%, 68.35%, and 68.40%, respectively, at 100 μg/ml. With the standard ascorbic acid, it was found to be 84.75% at 100 μg/ml. The IC50 values of the methanolic extract of DKV were 63.27 μg/ml, and marketed formulations (DKV-1, DKV-2, and DKV-3) were 63.13 μg/ml, 62.82 μg/ml, and 62.91 μg/ml, respectively, and ascorbic acid was 40.05 μg/ml. Conclusion: Results obtained suggest the antioxidant and free radical scavenging activity potential of DKV, and further it may be used as an antioxidant in associated diseases.
Keywords: absorption / bioavailability / Nanocarriers / Nanoparticles / nanotechnology / Oral Insulin Delivery / pancreas

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