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CKMT1B is a potential prognostic biomarker and associated with immune infiltration in Lower-grade glioma

Huadi Shi, , Zhi Song, Chun Huang
Published: 19 January 2021
PLOS ONE , Volume 16; doi:10.1371/journal.pone.0245524

Abstract: Background Lower-grade glioma (LGG) is the most common histology identified in glioma. CKMT1B has not been investigated in glioma. The purpose of this research was to investigate the prognostic value of CKMT1B and its correlation with immune infiltration in LGG. Methods We used Gene Expression Profiling Interactive Analysis (GEPIA) to analyze the expression of CKMT1B in LGG. Univariate and multivariate Cox regression analyses were used to assess the effect of CKMT1B expression and screened variables on survival. The correlation between CKMT1B and immune infiltration was evaluated by TIMER and CIBERSORT. Moreover, the possible biological functions of CKMT1B were studied by GSEA. The statistical analysis was conducted by R software. Results The expression of CKMT1B was significantly lower than the normal samples in LGG. Low expression of CKMT1B predicts a worse prognosis. Multivariate Cox analyses revealed that CKMT1B might be an independent favorable prognostic indicator. TIMER analysis revealed that CKMT1B expression level was related to immune infiltration. CIBERSORT analysis showed that CKMT1B expression was positively related to the infiltration level of activated mast cells and negatively related to macrophage M2 in LGG. Moreover, GESA showed that multiple cancer-related and immune-related gene sets were enriched in the low-CKMT1B group in the top 5 of the most significant differences. Conclusion CKMT1B is a prognostic biomarker with potential applications and associated with immune infiltration in Lower-grade glioma.
Keywords: prostate cancer / prognosis / macrophages / glioma / Immune cells / testicular cancer / mast cells / Cancers and neoplasms

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