mGlu5: A double-edged sword for aversive learning related therapeutics
Open Access
- 18 January 2021
- journal article
- Published by Episteme Health Inc in Neuroanatomy and Behaviour
Abstract
Aversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) has received attention due to the availability of drugs to utilize its role in learning and memory. In this review, we highlight preclinical studies examining the role of mGlu5 at various stages of aversive learning and its inhibition via extinction in order to gain a better understanding of its therapeutic potential. We suggest that mGlu5 has distinct roles at different stages of memory that not only makes it a tricky target, but a double-edged sword as a therapeutic. However, the selective involvement of mGlu5 in different memory stages allows for certain precision that could be harnessed clinically. We therefore suggest potential applications, limitations, and pitfalls when considering use of mGlu5 modulators as therapeutics. In addition, we recommend future studies to address important gaps in this literature, such as sex and age factors in light of anxiety disorders being more prevalent in those demographics.Keywords
This publication has 99 references indexed in Scilit:
- Pharmacological treatment of anxiety disorders: Current treatments and future directionsJournal of Anxiety Disorders, 2012
- The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analysesCognitive Therapy and Research, 2012
- Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1cNeurobiology of Learning and Memory, 2012
- Associative learning performance is impaired in zebrafish (Danio rerio) by the NMDA-R antagonist MK-801Neurobiology of Learning and Memory, 2011
- Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illnessJournal of Psychiatric Research, 2011
- Functional interaction of mGlu5 and NMDA receptors in aversive learning in ratsNeurobiology of Learning and Memory, 2011
- Development of Lifetime Comorbidity in the World Health Organization World Mental Health SurveysArchives of General Psychiatry, 2011
- Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addictionEuropean Journal of Pharmacology, 2010
- Preventing the return of fear in humans using reconsolidation update mechanismsNature, 2009
- Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasksBehavioural Brain Research, 2009