Background: Investigation of the probable causes of female infertility is complex and in many instances a compli-cated process. Aim of Study: To discuss the role of ultrasound in detection of causes of female infertility (including those disorders of cervix, ovaries, fallopian tube and uterus) illustrated by few cases. Patients and Methods: This cross sectional study was conducted on thirty female patients seeking fertility at Itay scan private radiology center, Itay Elbaroud and Al Dlangat General Hospitals, during the period from January 2018 to January 2020. All patients were subjected to examination using (GE healthcare Voluson P8 and Toshiba Nemio 30 and Medison Sono Ace R3) Ultrasound Machines. Results: Uterine abnormalities represent about 60%, cervical abnormalities represent 3.3% and ovarian abnormal-ities represent 23.3%, while tubal abnormalities represent 13.3% of the study group. Mean age of uterine abnormalities is about 30.5 years old, cervical abnormalities about 26 years old, ovarian abnormalities about 26 years old while mean age of tubal abnormalities is 30.5 years old in the study group. In most cases of female infertility in our study, ultrasound has been of great value: e.g. uterine malformations (sub septate and bicornuate uterus), endometrial abnormalities (endometrial polyp and focal endometrial hyperplasia), myometrial diseases (fibroids and uterine adenomyosis), tubal abnormalities (in-cluding hydrosalpinx and endometriosis), ovarian functional abnormalities (polycystic ovary) and cervical abnormalities (cervical masses). Conclusion: Ultrasound is a reliable tool in the diagnosis of many anatomical causes of female infertility and is com-parable to gold standard investigations in many circumstances, so we recommend it as primary investigation modality that could be complemented by other tools e.g. MRI, HSG, and laparoscopy when needed.