Propranolol decreases DRD3 and SLC1A2 gene expression in patients with essential tremor
Open Access
- 20 May 2020
- journal article
- research article
- Published by Universa Medicina in Universa Medicina
- Vol. 39 (2), 105-112
- https://doi.org/10.18051/univmed.2020.v39.105-112
Abstract
Background Essential tremor (ET) is the most common disease among movement disorders. Genes such as essential tremor 1-4 (ETM 1-4), HS1-binding protein-3 (HS1BP3), dopamine receptor D3 (DRD3), leucine-rich repeat and Ig domain containing 1 (LINGO1), glial high affinity glutamate transporter member 2 (SLC1A2), FUS, high temperature requirement A2 (HTRA2) and TENM4 had been shown to be responsible for the genetic inheritance of the disease. The aim of the present study was to investigate the effect of propranolol on the expression of DRD3, SLC1A2, and HTRA2 genes in patients with ET. Methods A study of non-randomized experimental design was conducted involving 76 subjects. They were divided into two groups: 38 patients with ET in the patient group (Group 1) and 38 healthy people in the control group (Group 2). DRD3, SLC1A2 and HTRA2 gene expressions were assessed before and after 8 weeks of propranolol treatment. Fahn-Tolosa-Marin tremor scale results were compared before and after propranolol administration. Kruskal Wallis test was used to determine differences in gene expressions between the groups. Results D3 dopamine receptor and SLC1A2 gene expression in the patient group appeared to be lower than in the control group (p<0.001). However, the HTRA2 gene expression level was significantly higher in the patient group (p<0.001). Conclusion D3 dopamine receptor and SLC1A2 gene expressions were decreased in ET patients which at first glance can be explained in relation to etiology, but after treatment it was not increased as expected but decreased even more.Keywords
This publication has 28 references indexed in Scilit:
- Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson diseaseProceedings of the National Academy of Sciences of the United States of America, 2014
- Decreased EAAT2 protein expression in the essential tremor cerebellar cortexActa Neuropathologica Communications, 2014
- Genetics of essential tremorNeurology, 2014
- Increased LINGO1 in the cerebellum of essential tremor patientsMovement Disorders, 2014
- Medical Treatment of Essential TremorJournal of Central Nervous System Disease, 2014
- HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNABiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
- Short sleep duration heralds essential tremor: A prospective, population‐based studyMovement Disorders, 2013
- Genetics of impulse control disorders in Parkinson’s diseaseJournal of Neural Transmission, 2012
- Mitochondrial Stress Signalling: HTRA2 and Parkinson's DiseaseInternational Journal of Cell Biology, 2012
- How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremorMovement Disorders, 2010