Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006–2017
Open Access
- 1 April 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 17 (7), 2397
- https://doi.org/10.3390/ijerph17072397
Abstract
Background: The purpose of the study is to evaluate the association between cognitive function and risk of all-cause and cardiovascular disease mortality during 10 years of the follow-up. Methods: 7087 participants were assessed in the baseline survey of the Health Alcohol Psychosocial Factors in Eastern Europe (HAPIEE) study in 2006–2008. During 10 years of follow-up, all-cause and CVD mortality risk were evaluated. Results: During 10 years of follow-up, 768 (23%) men and 403 (11%) women died (239 and 107 from CVD). After adjustment for sociodemographic, biological, lifestyle factors, and illnesses, a decrease per 1 standard deviation in different cognitive function scores increased risk for all-cause mortality (by 13%–24% in men, and 17%–33% in women) and CVD mortality (by 19%–32% in men, and 69%–91% in women). Kaplan-Meier survival curves for all-cause and CVD mortality, according to tertiles of cognitive function, revealed that the lowest cognitive function (1st tertile) predicts shorter survival compared to second and third tertiles (p < 0.001). Conclusions: The findings of this follow-up study suggest that older participants with lower cognitive functions have an increased risk for all-cause and CVD mortality compared to older participants with a higher level of cognitive function.Keywords
Funding Information
- Lietuvos Mokslo Taryba (SEN-02/2015)
- Wellcome Trust (081081/Z/06/Z)
- National Institute on Aging (1R0I AG23522)
This publication has 42 references indexed in Scilit:
- Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in NorwayPLOS ONE, 2018
- Cognitive impairment and stroke in elderly patientsVascular Health and Risk Management, 2016
- Incident Subjective Cognitive Decline Does Not Predict Mortality in the Elderly – Results from the Longitudinal German Study on Ageing, Cognition, and Dementia (AgeCoDe)PLOS ONE, 2016
- Effects of Mobility and Cognition on Risk of Mortality in Women in Late Life: A Prospective StudyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2015
- Racial Disparity in Cognitive and Functional Disability in Hypertension and All-Cause MortalityAmerican Journal of Hypertension, 2015
- Cognitive impairment, all-cause and cause-specific mortality among non-demented older adultsAge and Ageing, 2014
- Reaction Time and Mortality from the Major Causes of Death: The NHANES-III StudyPLOS ONE, 2014
- Smoking, Cognitive Function and Mortality in a U.S. National Cohort StudyInternational Journal of Environmental Research and Public Health, 2011
- Physical Activity, Cognitive Function, and Mortality in a US National CohortAnnals of Epidemiology, 2010
- Subjective cognitive functioning as a predictor of all cause mortality in an Israeli national sample of community dwelling older adultsInternational Journal of Geriatric Psychiatry, 2008