α9-Containing Nicotinic Receptors in Cancer
Open Access
- 21 January 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular Neuroscience
- Vol. 15, 805123
- https://doi.org/10.3389/fncel.2021.805123
Abstract
Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown that they are powerful regulators of responses that stimulate cancer processes such as proliferation, inhibition of apoptosis, and metastasis. It has also emerged that their modulation is a promising target for drug development. The aim of this review is to summarize recent data showing the involvement of these receptors in controlling the downstream signaling cascades involved in the promotion of cancer.This publication has 122 references indexed in Scilit:
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