A clinical case of treatment of a patient with laryngeal granular cell (Abrikossoff) tumor

Abstract

The study objective – present a clinical case of radical surgical treatment of a laryngeal granular cell tumor with invasion of cricoid cartilage and thyroid gland and show the importance of pathomorphological diagnosis.Case report. A 47‑year-old woman of European origin complained of progressive hoarseness that lasted for 8 months. We analyzed her clinical, laboratory, radiological, and pathomorphological data. At the preoperative stage, the tumor was classified as well differentiated squamous cell carcinoma (stage cT4aN0M0). Endoscopic examination revealed the exophytic part of the tumor with an infiltrative base and tuberous surface, pinkish, with signs of dyskeratosis and tumor invasion to the cartilage. Pathomorphological examination of biopsy specimens demonstrated well differentiated keratinizing squamous cell carcinoma. The patient has undergone laryngectomy, thyroidectomy, and selective cervical lymph node dissection. Pathomorphological and immunohistochemical examinations of surgical material verified granular cell tumor of the larynx (Abrikosov’s tumor) that was excised within healthy tissues (R0). Conclusion. The presented clinical case of such a rare pathology as a granular cell tumor of the larynx shows the importance of pathomorphological diagnosis and the use of additional immunohistochemical research methods for making an accurate diagnosis and differential diagnosis of squamous cell carcinoma and Abrikossoff tumor.