Oxidative Stress and Inflammation
Open Access
- 1 January 2019
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Open Journal of Immunology
- Vol. 09 (01), 1-20
- https://doi.org/10.4236/oji.2019.91001
Abstract
Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli. Debilitating diseases such as atherosclerosis, rheumatoid arthritis, and even cancer are the biggest pharmacological hurdles of today. Targeting inflammation is a broad task, since many mediators are involved in onset of particular disease. Among these many mediators, the reactive oxygen and nitrogen species generated by macrophages and neutrophils are of great interest because of their major contribution in establishment of chronic inflammation and cancer. This review elaborates the pathogenesis of inflammation based on involvement of reactive oxygen and nitrogen species and the activation of signalling cascades in response to oxidative stress. Understanding this would eventually give a clue for target based therapeutic approach in search of new effective anti-inflammatory drugs.Keywords
This publication has 86 references indexed in Scilit:
- Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in MiceThe Scientific World Journal, 2013
- Mitochondrial reactive oxygen species regulate hypoxic signalingCurrent Opinion in Cell Biology, 2009
- Is there more to aging than mitochondrial DNA and reactive oxygen species?The FEBS Journal, 2009
- NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and PathophysiologyAntioxidants and Redox Signaling, 2009
- Endothelial nitric oxide (NO) and its pathophysiologic regulationVascular Pharmacology, 2008
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicalsInternational Journal of Cancer, 2007
- Free radicals, metals and antioxidants in oxidative stress-induced cancerChemico-Biological Interactions, 2006
- Toll-like receptors and innate immunityNature Reviews Immunology, 2001
- Active Oxygen Species and the Functions of Phagocytic LeukocytesAnnual Review of Biochemistry, 1980