COVID-19 Vaccination of Individuals with Down Syndrome—Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated
Open Access
- 29 March 2022
- Vol. 10 (4), 530
- https://doi.org/10.3390/vaccines10040530
Abstract
Individuals with Down syndrome (DS) are among the groups with the highest risk for severe COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for individuals with DS may help improve uptake of vaccination. The T21RS COVID-19 Initiative launched an international survey to obtain information on safety and efficacy of COVID-19 vaccines for individuals with DS. De-identified survey data collected between March and December 2021 were analyzed. Of 2172 individuals with DS, 1973 (91%) had received at least one vaccine dose (57% BNT162b2), 107 (5%) were unvaccinated by choice, and 92 (4%) were unvaccinated for other reasons. Most participants had either no side effects (54%) or mild ones such as pain at the injection site (29%), fatigue (12%), and fever (7%). Severe side effects occurred in <0.5% of participants. About 1% of the vaccinated individuals with DS contracted COVID-19 after vaccination, and all recovered. Individuals with DS who were unvaccinated by choice were more likely to be younger, previously recovered from COVID-19, and also unvaccinated against other recommended vaccines. COVID-19 vaccines have been shown to be safe for individuals with DS and effective in terms of resulting in minimal breakthrough infections and milder disease outcomes among fully vaccinated individuals with DS.Funding Information
- LuMind IDSC Foundation (n/a)
- National Institute of Environmental Health Sciences (P30ES019776)
This publication has 31 references indexed in Scilit:
- Individuals with Down syndrome hospitalized with COVID-19 have more severe diseaseGenetics in Medicine, 2020
- Epidemiology of Covid-19 in a Long-Term Care Facility in King County, WashingtonThe New England Journal of Medicine, 2020
- National population‐based estimates for major birth defects, 2010–2014Birth Defects Research, 2019
- The REDCap consortium: Building an international community of software platform partnersJournal of Biomedical Informatics, 2019
- Generation of switched memory B cells in response to vaccination in Down syndrome children and their siblingsVaccine, 2015
- Vaccine hesitancy: Definition, scope and determinantsVaccine, 2015
- Influenza A/H1N1 Vaccination Response Is Inadequate in Down Syndrome Children When the Latest Cut-off Values Are UsedThe Pediatric Infectious Disease Journal, 2012
- Demographic Characteristics, Health Conditions, and Residential Service Use in Adults with Down Syndrome in 25 U.S. StatesIntellectual and Developmental Disabilities, 2012
- Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics supportJournal of Biomedical Informatics, 2008
- Immunogenicity and Safety of an Inactivated Hepatitis A Vaccine in Children With Down SyndromeJournal of Pediatric Gastroenterology and Nutrition, 2004