Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms
Open Access
- 9 July 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Chemistry
- Vol. 9, 724188
- https://doi.org/10.3389/fchem.2021.724188
Abstract
Recently, as our population increasingly ages with more pressure on bone and cartilage diseases, bone/cartilage tissue engineering (TE) have emerged as a potential alternative therapeutic technique accompanied by the rapid development of materials science and engineering. The key part to fulfill the goal of reconstructing impaired or damaged tissues lies in the rational design and synthesis of therapeutic agents in TE. Gold nanomaterials, especially gold nanoparticles (AuNPs), have shown the fascinating feasibility to treat a wide variety of diseases due to their excellent characteristics such as easy synthesis, controllable size, specific surface plasmon resonance and superior biocompatibility. Therefore, the comprehensive applications of gold nanomaterials in bone and cartilage TE have attracted enormous attention. This review will focus on the biomedical applications and molecular mechanism of gold nanomaterials in bone and cartilage TE. In addition, the types and cellular uptake process of gold nanomaterials are highlighted. Finally, the current challenges and future directions are indicated.Keywords
This publication has 94 references indexed in Scilit:
- The golden age: gold nanoparticles for biomedicineChemical Society Reviews, 2011
- Gold nanoparticles: preparation, properties, and applications in bionanotechnologyNanoscale, 2011
- Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of NanomaterialsSmall, 2011
- In VitroDifferentiation and Maturation of Human Embryonic Stem Cell into Multipotent CellsStem Cells International, 2011
- Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an AntioxidantBioscience, Biotechnology, and Biochemistry, 2010
- Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells through p38 MAPK PathwayACS Nano, 2010
- Epidemiology of OsteoarthritisClinics in Geriatric Medicine, 2010
- Methods in Mammalian Autophagy ResearchCell, 2010
- Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal developmentThe Journal of cell biology, 2007
- Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast DifferentiationConnective Tissue Research, 2003