Distinct Predictors and Comorbidities in Early Onset Type 2 Diabetes Mellitus Among Asian Indians
- 1 November 2017
- journal article
- research article
- Published by Mary Ann Liebert Inc in Metabolic Syndrome and Related Disorders
- Vol. 15 (9), 458-464
- https://doi.org/10.1089/met.2017.0047
Abstract
Background: The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, and the age of disease onset is falling. Although there is rising prevalence of early onset T2DM in India, little is known about their clinical characteristics and cardiovascular risks profiles. The aim of this study was to address this knowledge gap by comparing the characteristics of early onset T2DM and usual onset T2DM patients from our clinic population in India. Methods: We studied the clinical and biochemical parameters of 98 consecutive early onset T2DM patients of age Results: There was a strong component of family history of T2DM in early onset T2DM patients; however, no difference was observed in body mass index or waist circumference between the groups. When compared with usual onset group, the early onset T2DM patients were more hypertriglycedemic, with higher total cholesterol, higher total cholesterol/high-density lipoprotein (HDL) ratio, higher low-density lipoprotein levels, and lower HDL cholesterol. Early onset T2DM patients showed significantly worse glycemic control and rapid decline in insulin secretion compared with usual onset T2DM patients. Conclusions: Our results demonstrate that early onset T2DM in Asian Indians appears to be a disease phenotype with adverse risk factors having poor glycemic control and longer disease duration demanding strategies for novel clinical management.Keywords
This publication has 52 references indexed in Scilit:
- Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional studyThe Lancet Diabetes & Endocrinology, 2015
- The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010Diabetes, Obesity and Metabolism, 2013
- Type 2 diabetes in young Indigenous Australians in rural and remote areas: diagnosis, screening, management and preventionThe Medical Journal of Australia, 2012
- Early-onset type 2 diabetes in a Mexican survey: results from the National Health and Nutrition Survey 2006.Salud Publica de Mexico, 2010
- The Clinical Characteristics of the Newly Diagnosed Early Onset (< 40 Years Old) Diabetes in Outpatients' ClinicKorean Diabetes Journal, 2010
- Diabetes in Navajo YouthDiabetes Care, 2009
- High Prevalence of Diabetes and Cardiovascular Risk Factors Associated With Urbanization in IndiaDiabetes Care, 2008
- Type 2 diabetes in Asian Indian youthPediatric Diabetes, 2007
- Correlates of Type 2 diabetes mellitus in children, adolescents and young adults in north India: a multisite collaborative case‐control studyDiabetic Medicine, 2006
- Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projectionsDiabetes Care, 1998