Combined Brønsted-Base-Mediated Direct C-H Carboxylation of Heteroarenes with CO2
- 1 January 2021
- journal article
- review article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 103 (2), 592-608
- https://doi.org/10.3987/rev-20-sr(k)6
Abstract
This review article summarizes that the combined Bronsted-base system comprising LiO-t-Bu, CsF, and 18-crown-6 efficiently proceeds the direct carboxylation of electron-rich heteroarenes, such as benzothiophene and benzofuran, with CO2. Good functional group compatibility is displayed, allowing the use of Me, MeO, halogen, CN, ketone, and amide moieties. 3-Substituted indoles are also used for C-2 carboxylation, while double-carboxylation of 2-alkylheteroarenes is achieved by LiO-t-Bu and CsF.Keywords
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