Experimental Extracellular Matrix of the Xenoperitoneum: Comprehensive Assessment of a New Biological Material for Plastic Surgery of Anterior Abdominal Wall Defects

Abstract

A new biological implant, extracellular matrix of bovine peritoneum, was developed and obtained for plastic surgery of the anterior abdominal wall defects. The material was implanted to rats into the anterior abdominal wall. The content of rejection markers (TNF, IL-2, C-reactive protein) and the morphological picture of the implantation zone at the early stages (30 days) after surgery were evaluated. The studied material at this stage demonstrated adequate biocompatibility; the formation of mature, consistent contact with the tissues of the anterior abdominal wall and minimum tissue inflammatory reactions were observed.