Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches
Open Access
- 26 October 2021
- journal article
- review article
- Published by American Society for Microbiology in mSystems
- Vol. 6 (5), e0038821
- https://doi.org/10.1128/msystems.00388-21
Abstract
Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens, such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic, represent major global health challenges. While vaccination is an important part of the arsenal to counter the spread of viral diseases, it presents limitations and needs to be complemented by efficient therapeutic solutions. Intricate knowledge of host-pathogen interactions is a powerful tool to identify host-dependent vulnerabilities that can be exploited to dampen viral replication. Such host-directed antiviral therapies are promising and are less prone to the development of drug-resistant viral strains. Here, we first describe proteomics-based strategies that allow the rapid characterization of host-pathogen interactions. We then discuss how such data can be exploited to help prioritize compounds with potential host-directed antiviral activity that can be tested in preclinical models.Keywords
This publication has 128 references indexed in Scilit:
- A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutationsRetrovirology, 2013
- Cyclosporin A Inhibits the Influenza Virus Replication through Cyclophilin A-Dependent and -Independent PathwaysPLOS ONE, 2012
- A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cellsThe Journal of cell biology, 2012
- Global landscape of HIV–human protein complexesNature, 2011
- The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus InhibitorsPLoS Pathogens, 2011
- Enrichment techniques employed in phosphoproteomicsAmino Acids, 2011
- A Targeted Spatial-Temporal Proteomics Approach Implicates Multiple Cellular Trafficking Pathways in Human Cytomegalovirus Virion MaturationMolecular & Cellular Proteomics, 2010
- Ebola Virus Matrix Protein VP40 Uses the COPII Transport System for Its Intracellular TransportCell Host & Microbe, 2008
- Identification of Cellular Interaction Partners of the Influenza Virus Ribonucleoprotein Complex and Polymerase Complex Using Proteomic-Based ApproachesJournal of Proteome Research, 2006
- Drug repositioning: identifying and developing new uses for existing drugsNature Reviews Drug Discovery, 2004