Rate of Visual Field Progression in Eyes With Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study

Abstract

The Ocular Hypertension Treatment Study (OHTS) was a randomized clinical trial that demonstrated the beneficial effect of intraocular pressure (IOP) reduction in ocular hypertension.^1,2 Mathematical models derived from this data set, later validated in another clinical trial,³ allow the use of baseline variables (age, IOP, central corneal thickness, baseline visual field [VF], and optic disc status) to calculate the 5-year risk of conversion to primary open-angle glaucoma (POAG). Occurrence of optic disc hemorrhage (DH) detected on photographs by masked graders at the optic disc reading center grading stereo-optic disc photographs was shown to be a significant risk factor that increased the risk of conversion to POAG 6-fold in a univariable analysis and approximately 3-fold in a multivariable model.⁴