This work focuses on the analysis of a series of famous episodes that underline the prodigious birth and the exceptional destiny of Alexander the Great. First, the article examines the accounts of the Macedonian king's conception, due to the union of his mother Olympias with the king/magician Nectanebo, or with a snake, or with the god Ammon – depending on the different versions. Subsequently, the stories of the oracles foretelling Alexander's domination over the world and the premonitions that mark his rise to power are analyzed. Finally, the death omens are also taken into account. Summing up, this study deals with the elements related to Alexander's mythology and the reasons why the literary sources of the classical world present him as a being halfway between human and divine.