Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis
Open Access
- 21 August 2017
- journal article
- Published by Perio J
- Vol. 1 (1), 1-11
- https://doi.org/10.26810/2017.a1
Abstract
Background: The present study was conducted to evaluate the levels of interleukin (IL) – 17 in gingival crevicular fluid (GCF) and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Methods: This case-control study included a random sample of 40 female patients, aged 18 to 35 years, who were assigned to one of the following four groups (10 subjects each): group 1 included patients who underwent spontaneous preterm birth (PB) and were diagnosed with chronic periodontitis upon clinical examination (preterm/periodontitis); group 2 included patients who underwent spontaneous PB and who had a healthy periodontium upon clinical examination (preterm/healthy periodontium); group 3 included patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination (term/periodontitis); and group 4 included patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (term/healthy periodontium). GCF and placental tissue samples were obtained from each patient and IL-17 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: GCF levels of IL-17 were significantly higher (P=0.010) in patients with chronic periodontitis compared to those with a healthy periodontium. No significant differences were observed in IL-17 levels in placental tissue samples of all study groups. Conclusion: An association between chronic periodontitis and preterm labor could not be established based on IL-17 levels measured in the present study.Keywords
This publication has 38 references indexed in Scilit:
- Lack of association between maternal periodontal status and adverse pregnancy outcomes: a multicentric epidemiologic studyThe Journal of Maternal-Fetal & Neonatal Medicine, 2012
- Periodontal Status and Neutrophilic Enzyme Levels in Gingival Crevicular Fluid During Pregnancy and PostpartumThe Journal of Periodontology, 2010
- Periodontal Disease and Pregnancy OutcomesJournal of Pregnancy, 2010
- Examination of maternal gingival crevicular fluid for the presence of selected periodontopathogens implicated in the pre-term delivery of low birthweight infantsVirulence, 2010
- Periodontitis as a Risk Factor for Preterm Low Birth WeightYonsei Medical Journal, 2008
- Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort studyJournal of Clinical Periodontology, 2007
- Periodontal disease and perinatal outcomes: a case‐control studyJournal of Clinical Periodontology, 2006
- Burket’s Oral Medicine. Diagnosis and Treatment, 10th ednJournal of Orthodontics, 2003
- Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal ConditionActa Odontologica Scandinavica, 1964
- Effect of Chewing on Flow of Tissue Fluid into Human Gingival PocketsActa Odontologica Scandinavica, 1959