GABAergic neurons maturation is regulated by a delicate network
Open Access
- 16 December 2022
- journal article
- review article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 83 (1), 3-15
- https://doi.org/10.1002/jdn.10242
Abstract
Gamma-aminobutyric acid-expressing (GABAergic) neurons are implicated in a variety of neuropsychiatric disorders, such as epilepsy, anxiety, autism, and other pathological processes, including cerebral ischemia injury and drug addiction. Therefore, GABAergic neuronal processes warrant further research. The development of GABAergic neurons is a tightly controlled process involving the activity of multiple transcription and growth factors. Here, we focus on the gene expression pathways and the molecular modulatory networks that are engaged during the development of GABAergic neurons with the goal of exploring regulatory mechanisms that influence GABAergic neuron fate (i.e., maturation). Overall, we hope to provide a basis for clarifying the pathogenesis of neurodegenerative disorders.Keywords
Funding Information
- Education Department of Jilin Province (JJKH20170829KJ)
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