Mixed bivalent transition metal complexes of 1,10-phenanthroline and 2-aminomethylthiophenyl-4-bromosalicylaldehyde Schiff base: Spectroscopic, molecular modeling and biological activities
Open Access
- 31 December 2013
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 4 (4), 370-378
- https://doi.org/10.5155/eurjchem.4.4.370-378.803
Abstract
Mixed ligand complexes of M(II) {M = Cu(II), Ni(II), Co(II) and Zn(II)} with 1,10-phenanthroline (1,10-Phen) and Schiff base namely 2-aminomethylthiophenyl-4-bromosalicylaldehyde (ATS) have been synthesized. These metal chelates have been characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment and molar conductance. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff base (ATS) acts as monobasic bidentate coordinating through through azomethine-N and phenolic-oxygen groups. The geometry of the studied M(II) complexes has been fully optimized. The metal chelates have been screened for their antimicrobial activities using the disc diffusion method against different selected types of bacteria and fungi. In vitro antitumor activity assayed against two human cell lines colon (HCT116) and larynx (HEP2) cancer cells. Solution equilibrium studies were also investigated.Keywords
This publication has 64 references indexed in Scilit:
- Synthesis, characterization, biological activity and equilibrium studies of metal(II) ion complexes with tridentate hydrazone ligand derived from hydralazineSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012
- Synthesis, characterization, equilibrium study and biological activity of Cu(II), Ni(II) and Co(II) complexes of polydentate Schiff base ligandSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012
- Novel tumor chemotherapeutic agents and tumor radio-imaging agents: Potential tumor pharmaceuticals of ternary copper(II) complexesInorganic Chemistry Communications, 2005
- Metal Complexes for Therapy and Diagnosis of Drug ResistanceChemical Reviews, 1999
- Preparation and characterization of novel cyclic tetranuclear manganese (III) complexes: MnIII4(X-salmphen)6 (X-salmphenH2 = N,N′-di-substituted-salicylidene-1,3-diaminobenzene (X = H, 5-Br)Polyhedron, 1997
- Metal complexes of N-salicylideneamino acidsJournal of Inorganic Biochemistry, 1992
- Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNABiochemistry, 1987
- Synthesis, stereochemistry, and oxygenation of cobalt(II)-pyridoxal model complexes. A new family of chiral dioxygen carriersInorganic Chemistry, 1986
- Amino acid schiff base complexes of dimethyldichlorosilaneInorganica Chimica Acta, 1985
- Coordination modes of histidine. 6. Transamination in the 2-formylpyridine-amino acid-metal ion systems. Stereochemistry of zinc(II) and copper(II) complexes of N-(2-pyridylmethylidene)amino acidsInorganic Chemistry, 1983