Energy Balance and Weight Loss for Diabetes Remission
- 1 May 2020
- journal article
- Published by American Diabetes Association in Diabetes Spectrum
- Vol. 33 (2), 117-124
- https://doi.org/10.2337/ds20-0005
Abstract
Diabetes remission—the occurrence of durable normoglycemia without antidiabetic medications—has been demonstrated in some patients with type 2 diabetes who have achieved and sustained weight loss through lifestyle intervention or metabolic and bariatric surgery. Although this pursuit would represent a paradigm shift in our diabetes chronic care model, could diabetes remission become a routine treatment strategy in patients with type 2 diabetes? This article reviews the mechanisms by which weight loss can drive improvements in insulin sensitivity and β-cell function sufficient to normalize glycemia, treatment approaches that provide evidence for diabetes remission, and avenues for developing the research and discovery that will be required to make diabetes remission possible as part of the routine medical management of type 2 diabetes.Keywords
This publication has 44 references indexed in Scilit:
- Laparoscopic Roux-en-Y Gastric Bypass vs. Laparoscopic Sleeve Gastrectomy for Morbid Obesity and Diabetes Mellitus: A Meta-Analysis of Sixteen Recent StudiesHepato-Gastroenterology, 2012
- Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with DiabetesThe New England Journal of Medicine, 2012
- Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes StudyDiabetes Care, 2012
- Long-Term Persistence of Hormonal Adaptations to Weight LossThe New England Journal of Medicine, 2011
- Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?Journal of Clinical Endocrinology & Metabolism, 2011
- 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes StudyThe Lancet, 2009
- The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up studyThe Lancet, 2008
- Effect of Weight Loss With Lifestyle Intervention on Risk of DiabetesDiabetes Care, 2006
- Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminThe New England Journal of Medicine, 2002
- Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes MellitusAnnals of Surgery, 1995