Health equality, race and pharmacogenomics
- 4 August 2021
- journal article
- review article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 88 (1), 27-33
- https://doi.org/10.1111/bcp.14983
Abstract
Pharmacogenomics is increasingly moving into mainstream clinical practice. Careful consideration must be paid to inclusion of diverse populations in research, translation, and implementation, in the historical and social context of population stratification, to ensure that this leads to improvements in healthcare for all rather than increased health disparities. This review takes a broad and critical approach to the current role of diversity in pharmacogenomics and addresses potential pitfalls in order to raise awareness for prescribers. It also emphasizes evidence gaps and suggests approaches which may minimize negative consequences and promote health equality.This publication has 42 references indexed in Scilit:
- Impact of Race on Asthma Treatment Failures in the Asthma Clinical Research NetworkAmerican Journal of Respiratory and Critical Care Medicine, 2011
- Multiethnic Genetic Association Studies Improve Power for Locus DiscoveryPLOS ONE, 2010
- The Havasupai Indian Tribe Case — Lessons for Research Involving Stored Biologic SamplesThe New England Journal of Medicine, 2010
- HLA-B*5701 Screening for Hypersensitivity to AbacavirThe New England Journal of Medicine, 2008
- Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarinGenetics in Medicine, 2008
- BiDil: Assessing a Race-Based PharmaceuticalAnnals of Family Medicine, 2006
- Sequence Variations inPCSK9,Low LDL, and Protection against Coronary Heart DiseaseThe New England Journal of Medicine, 2006
- Racializing Drug Design: Implications of Pharmacogenomics for Health DisparitiesAmerican Journal of Public Health, 2005
- Illuminating BiDilNature Biotechnology, 2005
- When two tribes go to warNature, 2004