Study on Biological Mechanism of Vacuum Sealing Drainage in Clinical Application

Abstract

负压封闭引流技术(VSD)是临床上引入的一种治疗急、慢性创面的处理技术。目前认为VSD在创面修复中与透明质酸的代谢、CD44的表达、巨噬细胞趋化、肉芽组织生长等机制有关。上述机制相互促进，使创面愈合时间明显缩短，有效改善创面愈合处的色素沉着，尽量减少或避免对皮肤美观度的影响。本文将对负压封闭引流技术在针对临床应用中的生物机制加以研究，希望对后期创面修复及诊疗效果提供一定指导意义。 Vacuum sealing drainage (VSD) is a clinically introduced treatment technology for acute and chronic wounds. It is currently believed that VSD is related to hyaluronic acid metabolism, CD44 expression, macrophage chemotaxis, granulation tissue growth and other mechanisms in wound repair. The above mechanisms promote each other, shorten the healing time of the wound, effectively improve the pigmentation at the wound healing, and minimize or avoid the influence on the skin appearance. This article will study the biological mechanism of negative pressure sealing drainage technology in clinical application, hoping to provide a certain guiding significance for later wound repair and diagnosis and treatment.