Sulfotransferase activity contributes to long-term potentiation and long-term memory
Open Access
- 19 May 2022
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 29 (6), 155-159
- https://doi.org/10.1101/lm.053538.121
Abstract
A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term potentiation (LTP) in the hippocampal slices. In addition, inhibition of sulfation impairs long-term memory in a spatial memory task without affecting acquisition or short-term memory. Furthermore, LTP-inducing stimulus enhances protein tyrosine sulfation. These results suggest an important role for tyrosine sulfation in LTP and memory.Keywords
Funding Information
- Department of Biotechnology, India
This publication has 31 references indexed in Scilit:
- Focus on Molecules: SulfotyrosineExperimental Eye Research, 2012
- Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiationNeural Development, 2012
- Lack of protein‐tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomyEuropean Journal of Neuroscience, 2010
- Protein acetylation in synaptic plasticity and memoryNeuroscience & Biobehavioral Reviews, 2010
- Depolarization induces acetylation of histone H2B in the hippocampusNeuroscience, 2010
- Tyrosine phosphorylation: thirty years and countingCurrent Opinion in Cell Biology, 2009
- Carbohydrate post-glycosylational modificationsOrganic & Biomolecular Chemistry, 2007
- Tissue Residues, Metabolism, and Excretion of Radiolabeled Sodium Chlorate (Na[36Cl]O3) in RatsJournal of Agricultural and Food Chemistry, 2007
- Mice Deficient for the HNK-1 Sulfotransferase Show Alterations in Synaptic Efficacy and Spatial Learning and MemoryMolecular and Cellular Neuroscience, 2002
- Inhibition of tyrosine sulfation in the trans-Golgi retards the transport of a constitutively secreted protein to the cell surface.The Journal of cell biology, 1988