CLINICO-LABORATORY CHARACTERISTICS, RISK FACTORS AND OUTCOME OF ACUTE KIDNEY INJURY
Open Access
- 31 March 2021
- journal article
- research article
- Published by Khyber Medical University in Khyber Medical University Journal
- Vol. 13 (1), 30-5
- https://doi.org/10.35845/kmuj.2021.20430
Abstract
OBJECTIVE: To determine the clinico-laboratory characteristics, risk factors and outcome related to acute kidney injury (AKI) in hospitalized patients. METHODS: This prospective study on 101 consecutive patients admitted to the Northwest General Hospital & Research Centre, Peshawar, Pakistan was carried out from January-March 2019. Patients were staged according to Kidney Disease Improving Global Outcomes (KDIGO) guidelines and outcomes were measured in terms of in-hospital mortality and change in KDIGO staging. RESULTS: Majority (n=57/101; 56.43%) were males. Mean age of patients was 57.90±16.93 years. Twenty-seven (26.73%) patients were in AKI stage-I, 29 (28.71%) in stage-2 and 45 (44.55%) were in stage-3. Hypertension (n=74/101; 73.27%) was the commonest co-morbid condition. Sepsis (n=39/101; 38.61%) and hypovolemia (n=21/101; 20.8%) were most common risk factors for AKI. There was complete recovery in 43 (42.57%) patients. In-hospital mortality was 6.9% (n=7/101) and 57.1% (n=4/7) of these patients had KDIGO stage-3. Serum creatinine levels declined in 22 (21.78%) cases, remained static in 23 (22.8%) and worsened in 06 (5.9%) cases. Male gender and presence of hypovolumia (pCONCLUSION: Sepsis and hypovolemia constituted the major risk factors. Gender and hypovolemia were the significant factors between the survivors and non-survivors.Keywords
This publication has 18 references indexed in Scilit:
- Renal impairment according to acute kidney injury network criteria among ST elevation myocardial infarction patients undergoing primary percutaneous intervention: a retrospective observational studyClinical Research in Cardiology, 2014
- Contemporary Incidence, Predictors, and Outcomes of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary InterventionsJACC: Cardiovascular Interventions, 2014
- World Incidence of AKIClinical Journal of the American Society of Nephrology, 2013
- Contrast-induced nephropathyHeart Views, 2013
- Hospital-acquired acute kidney injury in medical, surgical, and intensive care unit: A comparative studyIndian Journal of Nephrology, 2013
- KDIGO Clinical Practice Guidelines for Acute Kidney InjuryNephron Clinical Practice, 2012
- Acute Kidney Injury and Mortality in Hospitalized PatientsAmerican Journal of Nephrology, 2012
- ForewordKidney International Supplements, 2012
- Different clinical outcomes of acute kidney injury according to acute kidney injury network criteria in patients between ST elevation and non-ST elevation myocardial infarctionInternational Journal of Cardiology, 2011
- The Risk Factors and Outcome of Acute Kidney Injury in the Intensive Care UnitsThe Korean Journal of Internal Medicine, 2010