STORI Plots Enable Accurate Tracking of Individual Ion Signals
- 11 September 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 30 (11), 2200-2203
- https://doi.org/10.1007/s13361-019-02309-0
Abstract
Charge detection mass spectrometry (CDMS) of low-level signals is currently limited to the analysis of individual ions that generate a persistent signal during the entire observation period. Ions that disintegrate during the observation period produce reduced frequency domain signal amplitudes, which lead to an underestimation of the ion charge state, and thus the ion mass. The charge assignment can only be corrected through an accurate determination of the time of ion disintegration. The traditional mechanisms for temporal signal analysis have severe limitations for temporal resolution, spectral resolution, and signal-to-noise ratios. Selective Temporal Overview of Resonant Ions (STORI) plots provide a new framework to accurately analyze low-level time domain signals of individual ions. STORI plots allow for complete correction of intermittent signals, the differentiation of single and multiple ions at the same frequency, and the association of signals that spontaneously change frequency.Keywords
Funding Information
- Thermo Fisher Scientific
- National Resource for Translational and Developmental Proteomics (Grant P41 GM108569)
This publication has 16 references indexed in Scilit:
- Charge Detection Mass Spectrometry with Almost Perfect Charge AccuracyAnalytical Chemistry, 2015
- Charge detection mass spectrometry for single ions with a limit of detection of 30 chargesInternational Journal of Mass Spectrometry, 2013
- Charge Detection Mass Spectrometry with Resolved Charge StatesJournal of the American Society for Mass Spectrometry, 2012
- Conetrap: A compact electrostatic ion trapNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2001
- A Gated Electrostatic Ion Trap To Repetitiously Measure the Charge and m/z of Large Electrospray IonsAnalytical Chemistry, 1997
- Automated assignment of charge states from resolved isotopic peaks for multiply charged ionsJournal of the American Society for Mass Spectrometry, 1995
- Isotopic beat patterns in Fourier transform ion cyclotron resonance mass spectrometry: implications for high resolution mass measurements of large biopolymersInternational Journal of Mass Spectrometry and Ion Processes, 1994
- Interpreting mass spectra of multiply charged ionsAnalytical Chemistry, 1989
- Time-frequency distributions-a reviewProceedings of the IEEE, 1989
- Effect of signal-to-noise ratio and number of data points upon precision in measurement of peak amplitude, position and width in fourier transform spectrometryChemometrics and Intelligent Laboratory Systems, 1986