This work analyzes in detail the possibility of granting protection through invention patents to human stem cells in Costa Rica. It was determined that, in the case of stem cell applications in Costa Rica, there have been multiple resolutions by the Patent Office, in some it has not been alleged that there is a patentability exception on stem cells, but in others it has been indicated that they are discoveries, that they are second uses, that they are inventions whose commercial exploitation must be prevented to protect public order, morality and the health or lives of people or animals. Also consisting of treatment methods in humans. The application of patentability exceptions contained in the Costa Rican regulations and the possibility of applying these excep-tions to stem cells are punctually analyzed. Each of the patentability requirements is analyzed to establish the possibilities and conditions that applications for stem cells should meet, so that they can be considered capable of being protected by patent in Costa Rica. It is concluded that, according to the Costa Rican legal framework, it is possible to obtained patents for stem cells from human beings.