Eruptive neurofibromas in pregnancy
Open Access
- 1 January 2020
- journal article
- research article
- Published by Medknow in Annals of African Medicine
- Vol. 19 (2), 150-152
- https://doi.org/10.4103/aam.aam_37_19
Abstract
Neurofibromatosis type 1 is the most common inherited nervous system disorder affecting 1 in 3500 live births. Cutaneous neurofibromas, the most characteristic feature of the disease, begin to appear in adolescence and continue throughout adulthood. Although neurofibromas have been noted to increase in size or number during pregnancy, there have been very few reports of eruption of a large number of lesions during this period. We report a case of a 24-year-old Nigerian woman of 32-week gestation who presented with a history of sudden eruption of neurofibromas during the current pregnancy and the previous one 3 years earlier. We discuss how hormones and growth factors contribute to the increase in numbers of neurofibromas during pregnancy, which is occasionally severe, as in our case, and the complications which may arise in the mother and fetus. Résumé La neurofibromatose de type 1 est le trouble du système nerveux héréditaire le plus répandu, touchant 1 naissance sur 3 500 naissances vivantes. Les neurofibromes cutanés, la caractéristique la plus caractéristique de la maladie, commencent à apparaître à l'adolescence et se poursuivent à l'âge adulte. Bien que l'on ait noté une augmentation de la taille ou du nombre des neurofibromes au cours de la grossesse, très peu de cas d'éruption d'un grand nombre de lésions ont été rapportés au cours de cette période. Nous rapportons le cas d'une femme nigérienne de 24 semaines de gestation nigérienne présentant des antécédents d'éruption soudaine de neurofibromes au cours de la grossesse en cours et la précédente trois ans plus tôt. Nous discutons de la manière dont les hormones et les facteurs de croissance contribuent à l'augmentation du nombre de neurofibromes pendant la grossesse, parfois sévère, comme dans notre cas, ainsi que des complications pouvant survenir chez la mère et le fœtus.Keywords
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