Voltammetric approach for pharmaceutical samples analysis; simultaneous quantitative determination of resorcinol and hydroquinone
Open Access
- 12 December 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Chemistry
- Vol. 16 (1), 1-12
- https://doi.org/10.1186/s13065-022-00905-y
Abstract
A simple and precise analytical approach developed for single and simultaneous determination of resorcinol (RC) and hydroquinone (HQ) in pharmaceutical samples using carbon paste electrode (CPE) modified with 1-Ethyl-3-methylimidazolium tetrafluoroborate as ionic liquid and ZnFe2O4 nanoparticle. A significant enhancement in the peak current and sensitivity of the proposed sensor observed by using modifiers in the composition of working electrode compared to bare CPE which is in accordance with the results obtained from electrochemical impedance spectroscopy investigations. Electrochemical investigations revealed a well-defined irreversible oxidation peak for RC over a wide concentration range from 3.0 µM to 500 µM in 0.1 M phosphate buffer solution (pH 6.0) with the linear regression equations of Ip (µA) = 0.0276 CRC (µM) + 0.5508 (R2 = 0.997). The limit of detection and quantification for RC analysis were found to be 1.46 µM and 4.88 µM, respectively. However, the obtained SW voltammograms for simultaneous determination of RC and HQ exhibited a desirable peak separation of about 360 mV potential difference and a satisfactory linear response over the range of 50–700 µM and 5-350 µM with the favorable correlation coefficient of 0.991 and 0.995, respectively. The diffusion coefficient (D) of RC and the electron transfer coefficient (α) at the surface of ZnFe2O4/NPs/IL/CPE estimated to be 2.83 × 10− 4 cm s− 1 and 0.76. The proposed sensor as a promising and low-cost method successfully applied for determination of RC in commercial pharmaceutical formulations such as the resorcinol cream of 2% O/W emulsion available on the market with the recovery of 98.47 ± 0.04.Keywords
Funding Information
- Kerman University of Medical Sciences (99001163)
This publication has 30 references indexed in Scilit:
- ZnO/Ag nanocomposite: An efficient catalyst for degradation studies of textile effluents under visible lightMaterials Science and Engineering: C, 2013
- Gold nanoparticle–graphene nanohybrid bridged 3-amino-5-mercapto-1,2,4-triazole-functionalized multiwall carbon nanotubes for the simultaneous determination of hydroquinone, catechol, resorcinol and nitriteAnalytical Methods, 2012
- Chromium removal from water by activated carbon developed from waste rubber tiresEnvironmental Science and Pollution Research, 2012
- Removal of the hazardous dye—Tartrazine by photodegradation on titanium dioxide surfaceMaterials Science and Engineering: C, 2011
- Electrochemical behavior of catechol, resorcinol and hydroquinone at graphene–chitosan composite film modified glassy carbon electrode and their simultaneous determination in water samplesElectrochimica Acta, 2011
- Application of multielectrode array modified with carbon nanotubes to simultaneous amperometric determination of dihydroxybenzene isomersSensors and Actuators B: Chemical, 2009
- Ultrasensitive flow-injection electrochemical method for detection of anticancer drug tamoxifenTalanta, 2009
- Determination of phenol, resorcinol and hydroquinone in air samples by synchronous fluorescence using partial least-squares (PLS)Talanta, 2006
- Direct simultaneous determination of dihydroxybenzene isomers at C-nanotube-modified electrodes by derivative voltammetryJournal of Electroanalytical Chemistry, 2005
- Simultaneous determination of cloramphenicol, salicylic acid and resorcinol by capillary zone electrophoresis and its application to pharmaceutical dosage formsTalanta, 2003