Evaluation of In Vitro Anti-Proliferative Activity of St. John’s Wort (Hypericum perforatum Linn.) Plant Extract on Cervix Adenocarcinoma

Abstract

St. John’s wort (Hypericum perforatum L.) is a medicinal plant used for many diseases. Hypericum perforatum has strong historical background about the therapeutic potential. In the present study, we have investigated the cytotoxic activity of the Hypericum perforatum against cultured cervix adenocarcinoma (HeLa) cell line. Antiproliferative effects of Hypericum perforatum on HeLa cells were evaluated by means of the XTT Cell Proliferation Kit (Biological Industries, Israel) according to manufacturer's instructions, and then the IC50 value was calculated. IC50 value of Hypericum perforatum was found as 120 μg/mL. Therefore, this plant may be a potential natural antitumor drug for cervix adenocarcinoma.