Acupuncture Treatment of Guillain–Barré Syndrome After Using Immune Checkpoint Inhibitors: A Case Report
Open Access
- 2 June 2022
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neurology
- Vol. 13, 908282
- https://doi.org/10.3389/fneur.2022.908282
Abstract
Guillain–Barré syndrome(GBS) is an autoimmune-mediated peripheral neuropathy. Immune checkpoint inhibitors (ICIs) are the standard treatment for cancer and may lead to immune-related adverse events (irAEs) such as GBS. Corticosteroids, plasma exchange (PE), and intravenous immunoglobulin (IVIG) are currently accepted treatments for ICI-induced GBS. However, there are still adverse reactions, and the effect of relieving symptoms is not as good as expected. Safe and effective complementary replacement therapy to alleviate GBS symptoms and ameliorate the quality of life is urgently required. In this case, a 63-year-old man received ICI therapy and antitumor chemotherapy for lung malignancy. After two courses of treatment, the patient gradually developed limb weakness, numbness, and pain at the ends of the limbs, with cerebrospinal fluid (CSF) albuminocytological dissociation, and electromyography (EMG) suggested demyelinating changes and was diagnosed as GBS. Although the patient received high doses of intravenous gamma globulin and limb weakness symptoms were alleviated, there was still significant numbness and pain in the extremities. After four times of acupuncture treatments, the patient complained that the symptoms of limb numbness and fatigue were significantly alleviated without any discomfort. This case report may provide a new alternative and complementary therapy for immune checkpoint inhibitor-induced GBS, but more definitive and robust evidence is needed to support its efficacy.This publication has 50 references indexed in Scilit:
- Glycolipid antigens and autoantibodies in autoimmune neuropathiesTrends in Immunology, 2013
- Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-AnalysisNeuroepidemiology, 2011
- Early recognition of poor prognosis in Guillain-Barré syndromeNeurology, 2011
- Pain in Guillain-Barré syndromeNeurology, 2010
- Distinguishing acute-onset CIDP from fluctuating Guillain-Barré syndromeNeurology, 2010
- Axonal variant of Guillain-Barré syndrome associated with Campylobacter infection in BangladeshNeurology, 2010
- The Epidemiology of Guillain-Barré Syndrome WorldwideNeuroepidemiology, 2008
- Infections and vaccinations preceding childhood Guillain-Barré syndrome: a prospective studyEuropean Journal of Pediatrics, 2006
- Diagnosis, Management, and Evaluation of Chemotherapy-Induced Peripheral NeuropathySeminars in Oncology, 2006
- Motoneuron-disease-like disorder after ganglioside therapyThe Lancet, 1991