SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants
Open Access
- 16 January 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 78 (6), 2641-2664
- https://doi.org/10.1007/s00018-020-03723-4
Abstract
Across all species, transcription factors (TFs) are the most frequent targets of SUMOylation. The effect of SUMO conjugation on the functions of transcription factors has been extensively studied in animal systems, with over 200 transcription factors being documented to be modulated by SUMOylation. This has resulted in the establishment of a number of paradigms that seek to explain the mechanisms by which SUMO regulates transcription factor functions. For instance, SUMO has been shown to modulate TF DNA binding activity; regulate both localization as well as the abundance of TFs and also influence the association of TFs with chromatin. With transcription factors being implicated as master regulators of the cellular signalling pathways that maintain phenotypic plasticity in all organisms, in this review, we will discuss how SUMO mediated regulation of transcription factor activity facilitates molecular pathways to mount an appropriate and coherent biological response to environmental cues.Keywords
Funding Information
- Biotechnology and Biological Sciences Research Council (BB/M002136/1)
This publication has 215 references indexed in Scilit:
- DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZsDevelopmental Cell, 2010
- Proteasome-Mediated Turnover of the Transcription Coactivator NPR1 Plays Dual Roles in Regulating Plant ImmunityCell, 2009
- What Was the Set of Ubiquitin and Ubiquitin-Like Conjugating Enzymes in the Eukaryote Common Ancestor?Journal of Molecular Evolution, 2009
- Lid2 Is Required for Coordinating H3K4 and H3K9 Methylation of Heterochromatin and EuchromatinCell, 2008
- Transcriptional factor interaction: a central step in DELLA functionCurrent Opinion in Genetics & Development, 2008
- DELLAs Control Plant Immune Responses by Modulating the Balance of Jasmonic Acid and Salicylic Acid SignalingCurrent Biology, 2008
- An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in ArabidopsisDevelopmental Cell, 2007
- Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl InteractionJournal of Molecular Biology, 2007
- Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1Cell, 2004
- Structure of ubiquitin refined at 1.8ÅresolutionJournal of Molecular Biology, 1987