Maintenance of conditioned place avoidance induced by gastric malaise requires NMDA activity within the ventral hippocampus
Open Access
- 16 August 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 28 (9), 270-276
- https://doi.org/10.1101/lm.052720.120
Abstract
It has been reported that during chemotherapy treatment, some patients can experience nausea before pharmacological administration, suggesting that contextual stimuli are associated with the nauseating effects. There are attempts to reproduce with animal models the conditions under which this phenomenon is observed to provide a useful paradigm for studying contextual aversion learning and the brain structures involved. This manuscript assessed the hippocampus involvement in acquiring and maintaining long-term conditioned place avoidance (CPA) induced by a gastric malaise-inducing agent, LiCl. Our results demonstrate that a reliable induction of CPA is possible after one acquisition trial. However, CPA establishment requires a 20-min confinement in the compartment associated with LiCl administration. Interestingly, both hippocampal regions seem to be necessary for CPA establishment; nonetheless, inactivation of the ventral hippocampus results in a reversion of avoidance and turns it into preference. Moreover, we demonstrate that activation of dorsal/ventral hippocampal NMDA receptors after CS–US association is required for long-term CPA memory maintenance.Keywords
Funding Information
- DGAPA-PAPIIT (IA201420)
- CONACyT (CB250880)
- DGAPA PAPIIT (IN212919)
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