The influence of astrocytes on the width of orientation hypercolumns in visual cortex: A computational perspective

Abstract

Orientation preference maps (OPMs) are present in carnivores (such as cats and ferrets) and primates but are absent in rodents. In this study we investigate the possible link between astrocyte arbors and presence of OPMs. We simulate the development of orientation maps with varying hypercolumn widths using a variant of the Laterally Interconnected Synergetically Self-Organizing Map (LISSOM) model, the Gain Control Adaptive Laterally connected (GCAL) model, with an additional layer simulating astrocytic activation. The synaptic activity of V1 neurons is given as input to the astrocyte layer. The activity of this astrocyte layer is now used to modulate bidirectional plasticity of lateral excitatory connections in the V1 layer. By simply varying the radius of the astrocytes, the extent of lateral excitatory neuronal connections can be manipulated. An increase in the radius of lateral excitatory connections subsequently increases the size of a single hypercolumn in the OPM. When these lateral excitatory connections become small enough the OPM disappears and a salt-and-pepper organization emerges. Columns of neurons in the primary visual cortex (V1) are known to be tuned to visual stimuli containing edges of a particular orientation. The arrangement of these cortical columns varies across species. In many species such as in ferrets, cats, and monkeys a topology preserving map is observed, wherein similarly tuned columns are observed in close proximity to each other, resulting in the formation of Orientation Preference Maps (OPMs). The width of the hypercolumns, the fundamental unit of an OPM, also varies across species. However, such an arrangement is not observed in rodents, wherein a more random arrangement of these cortical columns is reported. We explore the role of astrocytes in the arrangement of these cortical columns using a self-organizing computational model. Invoking evidence that astrocytes could influence bidirectional plasticity among effective lateral excitatory connections in V1, we introduce a mechanism by which astrocytic inputs can influence map formation in the neuronal network. In the resulting model-generated OPMs the radius of the hypercolumns is found to be correlated with that of astrocytic arbors, a feature that finds support in experimental studies.