Extracellular Vesicles in Cervical Cancer and HPV Infection
Open Access
- 20 June 2021
- Vol. 11 (6), 453
- https://doi.org/10.3390/membranes11060453
Abstract
Since their description, extracellular vesicles (EVs) have shown growing relevance in cancer progression. These cell structures contain and transfer molecules such as nucleic acids (including DNA and RNA), proteins, and lipids. Despite the rising information about EVs’ relationship with cancer, there is still scarce evidence about their content and function in cervical cancer. Interestingly, the composition and purposes of some cellular molecules and the expression of oncogenic proteins packaged in EVs seem modified in HPV-infected cells; and, although only the E6 oncogenic protein has been detected in exosomes from HPV-positive cells, both E6/E7 oncogenes mRNA has been identified in EVs; however, their role still needs to be clarified. Given that EVs internalizing into adjacent or distant cells could modify their cellular behavior or promote cancer-associated events like apoptosis, proliferation, migration, or angiogenesis in receptor cells, their comprehensive study will reveal EV-associated mechanisms in cervical cancer. This review summarizes the current knowledge in composition and functions of cervical cancer and HPV Infection-derived EVs.Keywords
This publication has 80 references indexed in Scilit:
- Increased Exosomal MicroRNA-21 and MicroRNA-146a Levels in the Cervicovaginal Lavage Specimens of Patients with Cervical CancerInternational Journal of Molecular Sciences, 2014
- The Complete Exosome Workflow Solution: From Isolation to Characterization of RNA CargoBioMed Research International, 2013
- Human Papillomavirus Mutational Insertion: Specific Marker of Circulating Tumor DNA in Cervical Cancer PatientsPLOS ONE, 2012
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Tumour microvesicles contain retrotransposon elements and amplified oncogene sequencesNature Communications, 2011
- Survivin is released from cancer cells via exosomesApoptosis, 2010
- Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living CellsOnline Journal of Public Health Informatics, 2010
- Astrocytes and Glioblastoma cells release exosomes carrying mtDNAJournal of Neural Transmission, 2009
- Localization of the Epstein–Barr virus protein LMP 1 to exosomesJournal of General Virology, 2003
- Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes.The Journal of cell biology, 1983