Guillain-Barré-Syndrom nach Exposition mit Influenza
- 14 April 2012
- journal article
- english abstract
- Published by Springer Science and Business Media LLC in Der Nervenarzt
- Vol. 83 (6), 714-730
- https://doi.org/10.1007/s00115-012-3479-8
Abstract
Das Guillain-Barré-Syndrom (GBS) ist eine sporadisch auftretende, autoimmun-vermittelte akute Polyradikuloneuritis, die häufig nach Infektionen auftritt. Ein Zusammenhang wird auch seit Jahren mit verschiedenen Impfungen, insbesondere der Influenzaschutzimpfung diskutiert. Die vorliegende Arbeit fasst die Diskussion eines Zusammenhanges zwischen GBS und vorangegangener Infektion oder Impfung mit Influenza einschließlich der Impfung gegen das Influenzavirus A/H1N1/2009 zusammen. Nach der derzeitigen Datenlage erscheint das Risiko der Impfungen, sofern es überhaupt vorhanden ist, mit einem geschätzten Fall eines GBS innerhalb von 6 Wochen nach Impfung bei 1 Mio. verimpfter Dosen sehr gering zu sein. Aktuelle Studien weisen darauf hin, dass auch Infektionen mit Influenza eine Rolle bei der Entstehung des GBS spielen könnten. Guillain-Barré Syndrome (GBS) is an acquired, monophasic inflammatory polyradiculoneuritis of autoimmune origin, which occurs after infection and occasionally also after vaccination. Seasonal and pandemic influenza vaccines have in particular been implicated as triggers for GBS. However, a number of recent studies indicate that infection with influenza virus may also cause GBS. This review summarizes the epidemiological and experimental data of the association of GBS with exposure to influenza antigens by immunization (including vaccines against A/H1N1/2009) and infection. Vaccination against influenza is associated with a very low risk for the occurrence of GBS. In contrast infection with influenza may play a more important role as a triggering factor for GBS than previously assumed.Keywords
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