Efficient deprotection of Boc group in amines and sulfamides using Dawson heteropolyacid catalyst
- 30 September 2012
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 3 (3), 305-309
- https://doi.org/10.5155/eurjchem.3.3.305-309.610
Abstract
A series of sulfamides containing two protecting groups have been synthesized starting from N-benzoylaminoacids derivatives of (glycine, alanine, valine, leucine, phenylalanine), chlorosulfonylisocyanate and primary amines. Selective deprotection of the cyclic or linear sulfamides and amines has been achieved by treatment with heteropolyacid, which is easily recoverable and reusable. This method represents a reasonable alternative to the previous reported deprotection procedures.Keywords
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