Androgen receptor, oxidative stress and inflammation at the crossroads of skin diseases
- 26 July 2022
- journal article
- Published by Peertechz Publications Private Limited in International Journal of Dermatology and Clinical Research
- Vol. 8 (1), 012-015
- https://doi.org/10.17352/2455-8605.000045
Abstract
Skin is the largest organ of the human body and acts as a protective barrier as our first line of defense. The development of effective treatments for skin diseases represents one of the biggest challenges in drug discovery. The pathogenesis of many skin disorders is complex and multifactorial.Keywords
This publication has 18 references indexed in Scilit:
- Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stressScientific Reports, 2017
- ASC-J9® suppresses castration resistant prostate cancer progression via degrading the enzalutamide-induced androgen receptor mutant AR-F876LCancer Letters, 2016
- A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophyHuman Molecular Genetics, 2016
- New Therapeutic Approach to Suppress Castration-Resistant Prostate Cancer Using ASC-J9 via Targeting Androgen Receptor in Selective Prostate CellsThe American Journal of Pathology, 2012
- The role of androgen and androgen receptor in skin-related disordersArchiv für dermatologische Forschung, 2012
- Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expressionJCI Insight, 2009
- ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptorNature Medicine, 2007
- Oxidative Stress in the Pathogenesis of Skin DiseaseJournal of Investigative Dermatology, 2006
- Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathwayNature Immunology, 2002
- Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glandsJournal of Endocrinology, 1992