Strategies for the synthesis of brevipolides
Open Access
- 14 September 2021
- journal article
- review article
- Published by Beilstein Institut in Beilstein Journal of Organic Chemistry
- Vol. 17 (1), 2399-2416
- https://doi.org/10.3762/bjoc.17.157
Abstract
In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities.Keywords
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