Phytochemical investigation of Ludwigia adscendens subsp. diffusa aerial parts in context of its biological activity
Open Access
- 10 December 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Chemistry
- Vol. 16 (1), 1-9
- https://doi.org/10.1186/s13065-022-00909-8
Abstract
Ludwigia adscendens subsp. diffusa (Onagraceae), an important aquatic herb widely distributed in the Nile River and canals in Egypt. The goal of the current study is to investigate the phytochemical composition of L. adscendens aerial parts n-butanol and ethyl acetate fractions and screening of its biological activities. Phytochemical investigation of L. adscendens resulted in the isolation and purification of eleven compounds belonging to flavonoids, saponins, triterpenoids, and oligosaccharides, of which one compound was identified as new using different spectroscopic techniques. Compound 2 was identified as a new compound namely, 3-O-[β-D-glucopyranoside (1 → 4) α-L-rhamnopyranoside]-23-O-feruloyl-hederagenin-28-O-[α-L-rhamnopyranoside (1 → 2) β-D-glucopyranoside], along with other 10 well know compounds. Furthermore, antidiabetic, hepatoprotective and cytotoxic activities of n-butanol and ethyl acetate fractions were investigated in vitro, revealing that ethyl acetate fraction was the most active as antidiabetic (IC50 = 62.3 µg/mL), hepatoprotective (IC50 = 80.75 µg/mL), and cytotoxic against human prostate cancer cell line (IC50 = 52.2 µg/mL). Collectively, L. adscendens aerial part is rich with a myriad of phytochemicals with potential health benefits.Keywords
Funding Information
- Egyptian Russian University
This publication has 20 references indexed in Scilit:
- Isolation and identification of a new neo-clerodane diterpenoid fromTeucrium chamaedrysL.Natural Product Research, 2015
- Chemical Constituents, Quantitative Analysis and Antioxidant Activities ofEchinacea purpurea(L.) Moench andEchinacea pallida(Nutt.) Nutt.Journal of Food Biochemistry, 2015
- Influence of polyphenol extract from evening primrose (Oenothera paradoxa) seeds on human prostate and breast cancer cell linesPostępy Higieny I Medycyny Doświadczalnej, 2014
- New polyglucopyranosyl and polyarabinopyranosyl of fatty acid derivatives from the fruits of Lycium chinense and its antioxidant activityFood Chemistry, 2013
- A novel saponin from Manilkara hexandra seeds and anti-inflammatory activityMedicinal Chemistry Research, 2013
- Therapeutic potential of octyl gallate isolated from fruits ofTerminalia bellericain streptozotocin-induced diabetic ratsPharmaceutical Biology, 2013
- Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studiesWorld Journal of Gastroenterology, 2008
- Flavonoids and biological activities ofJussiaea repensNatural Product Research, 2007
- Oleanane-type triterpenes from Ludwigia octovalvisJournal of Asian Natural Products Research, 2007
- Three New Oleanane-Type Triterpenes from Ludwigia octovalvis with Cytotoxic Activity against Two Human Cancer Cell LinesJournal of Natural Products, 2003