ARTERY-FIRST APPROACH FOR PANCREATODUODENAL RESECTIONS. SAFETY AND ONCOLOGICAL BENEFIT (LITERATURE REVIEW)

Abstract

The results of treatment of patients with malignant neoplasms of the biliopancreatoduodenal zone remain unsatisfactory. With this localization, pancreatoduodenal resection (PDR) remains the only radical surgical intervention. It is more advisable to start with non-surgical treatment, in the presence of arterial invasion of magistral vessels. This served as an impetus for the development of approaches to determine the presence of tumor invasion in the superior mesenteric artery at the early stage of the operation. The surgical goal of PDR remains to minimize contact with the tumor prior to mobilization and ligation of the supply vessels, as well as to increase the edge of the resection around the superior mesenteric artery. To achieve this goal, a number of researchers have proposed various approaches to the superior mesenteric artery during pancreatoduodenal resection, combined “artery-first approach”.An analysis of the existing artery-first techniques for pancreatoduodenal resections, as well as their effect on the treatment results of patients with periampullary malignant neoplasms, is carried out. When conducting literary searches, the databases Pubmed, Сochrane, EMBASE were used using the MESH keywords “Pancreaticoduodenectomy” in combination with the phrase “artery first”. During this search, 157 articles were found. After further analysis, 53 scientific papers were included in the literature review.Modern studies show a decrease in intraoperative blood loss, a decrease in the frequency of postoperative pancreatic fistulas and gastrostasis, as well as an increase in the frequency of R0 resection when this approach is followed. An unambiguous conclusion about the effectiveness of the artery first accesses when performing pancreatoduodenal resection requires further well-planned randomized clinical trials with a large number of patients.