Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia
Open Access
- 17 October 2019
- journal article
- research article
- Published by MDPI AG in Brain Sciences
- Vol. 9 (10), 279
- https://doi.org/10.3390/brainsci9100279
Abstract
Oxcarbazepine, an antiepileptic drug, has been reported to modulate voltage-dependent sodium channels, and it is commonly used in epilepsy treatment. In this study, we investigated the neuroprotective effect of oxcarbazepine in the hippocampus after transient ischemia in gerbils. Gerbils randomly received oxcarbazepine 100 or 200 mg/kg before and after transient ischemia. We examined its neuroprotective effect in the cornu ammonis 1 subfield of the gerbil hippocampus at 5 days after transient ischemia by using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluoro-Jade B histofluorescence staining for neuroprotection, and by using glial fibrillary protein and ionized calcium-binding adapter molecule 1 immunohistochemistry for reaction of astrocytes and microglia, respectively. Pre- and post-treatment with 200 mg/kg of oxcarbazepine, but not 100 mg/kg of oxcarbazepine, protected pyramidal neurons of the cornu ammonis 1 subfield from transient ischemic damage. In addition, pre- and post-treatment with oxcarbazepine (200 mg/kg) significantly ameliorated astrocytes and microglia activation in the ischemic cornu ammonis 1 subfield. In brief, our current results indicate that post-treatment as well as pre-treatment with 200 mg/kg of oxcarbazepine can protect neurons from ischemic insults via attenuation of the glia reaction.This publication has 53 references indexed in Scilit:
- Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease modelProceedings of the National Academy of Sciences of the United States of America, 2012
- Primary prevention of stroke: blood pressure, lipids, and heart failureEuropean Heart Journal, 2011
- Autophagy and protein aggregation after brain ischemiaJournal of Neurochemistry, 2010
- An ultrastructural study of cell death in the CA1 pyramidal field of the hippocapmus in rats submitted to transient global ischemia followed by reperfusionJournal of Anatomy, 2007
- Molecular Targets for Antiepileptic Drug DevelopmentNeurotherapeutics, 2007
- Mechanisms that Result in Damage During and Following Cerebral IschemiaNeuroscience & Biobehavioral Reviews, 1997
- Postischemic hyperactivity in the Mongolian gerbil correlates with loss of hippocampal neurons.Behavioral Neuroscience, 1997
- Felbamate Protects CA1 Neurons From Apoptosis in a Gerbil Model of Global IschemiaStroke, 1996
- Delayed neuronal death in the gerbil hippocampus following ischemiaBrain Research, 1982