Ion-Neutral Collision Effects on Ion Trapping and Pseudopotential Depth in Ion Trap Mass Spectrometry
- 28 October 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 30 (12), 2750-2755
- https://doi.org/10.1007/s13361-019-02344-x
Abstract
Ion trapping using radio-frequency (RF) devices has been widely used in mass spectrometry (MS). The pseudopotential well (PW) model enables the use of a pseudopotential depth, D, to evaluate the ion trapping capability of the RF devices in the pure electric field. It remains unclear how gas pressures regulate the ion trapping and D. Here, we calculated the D of a linear ion trap (LIT) from 1 mTorr to 2 Torr, a pressure range critical for the operation of the RF devices, through ion cloud simulations. Compared with the case of pure electric field, ion-neutral collision effects at pressures of 1 to 100 mTorr were beneficial for the ion trapping and revealed an optimal trapping depth, D, at around 10 mTorr. We explained the mechanism and validated the observation via ion trapping experiments performed in a home-made dual LIT mass spectrometer. We also showed that near the stability boundary, the RF heating became comparable with the D, which led to the decrement of ion trapping capability characterized by the available D.Keywords
Funding Information
- National Key R&D Program of China (2018YFF0109500)
- National Natural Science Foundation of China (21705090, 21627807)
This publication has 34 references indexed in Scilit:
- Miniature Mass SpectrometersAnnual Review of Analytical Chemistry, 2009
- The ion funnel: Theory, implementations, and applicationsMass Spectrometry Reviews, 2009
- Ion mobility–mass spectrometryJournal of Mass Spectrometry, 2008
- Microfabricated Quadrupole Ion Trap for Mass Spectrometer ApplicationsPhysical Review Letters, 2006
- Ambient Mass SpectrometryScience, 2006
- Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray IonizationScience, 2004
- High-pressure ion trap mass spectrometryRapid Communications in Mass Spectrometry, 2004
- A new linear ion trap mass spectrometerRapid Communications in Mass Spectrometry, 2002
- Electromagnetic traps for charged and neutral particlesReviews of Modern Physics, 1990
- Quadrupole mass analyzers: Performance, design and some recent applicationsMass Spectrometry Reviews, 1986