Synthesis, reactions and applications of naphthofurans: A review
Open Access
- 30 September 2021
- journal article
- review article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 12 (3), 340-359
- https://doi.org/10.5155/eurjchem.12.3.340-359.2126
Abstract
Considering the highly important biological and medicinal properties of naphthofurans, the synthesis of these heterocycles has attracted the interest of medicinal and organic chemists. This review aims to describe the different strategies developed so far for the synthesis of naphthofurans and their applications and the literature reports for the period of 2000 to early 2020. After a brief introduction of the types of naphthofurans and their biological activities, the different synthetic approaches such as chemical and photochemical, methods are described and organized on the basis of the catalysts and the other reagents employed in the syntheses. Some of the reactions have been applied successfully to the synthesis of biologically important compounds.Keywords
This publication has 61 references indexed in Scilit:
- Modified eremophilanes and anti-inflammatory activity of Psacalium cirsiifoliumJournal of the Brazilian Chemical Society, 2013
- Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenesEuropean Journal of Medicinal Chemistry, 2008
- Synthesis and biological study of some new naphtho[2,1-b]furan and related heterocyclic systemsJournal of Chemical Research, 2006
- Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2,1-b]furan-carboxylatesIl Farmaco, 2003
- Chemical Constituents of Avicennia alba. Isolation and Structural Elucidation of New Naphthoquinones and Their Analogues.CHEMICAL & PHARMACEUTICAL BULLETIN, 2000
- 7-Methoxy-2-nitronaphtho(2, l-b)furan (R7000)-induced mutation spectrum in the lacI gene of Escherichia coli: influence of SOS mutagenesisCarcinogenesis: Integrative Cancer Research, 1996
- Synthesis of 1,2,3-thiadiazolo[5,4-d]pyrimidinesChemistry of Heterocyclic Compounds, 1996
- Synthesis of Naphthofuran-2(3H)-one Derivatives by Palladium-Catalyzed Three-Component Coupling Using Naphthols, Aldehydes, and Carbon MonoxideThe Journal of Organic Chemistry, 1996
- Pharmacologically Active Components from a Peruvian Medicinal Plant Huira-Huira (Culcitium canescens H. & B.).CHEMICAL & PHARMACEUTICAL BULLETIN, 1994
- Synthesis of (.+-.)-heritol, a sesquiterpene lactone belonging to the aromatic cadinane group.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990