Moving the Needle on Atherosclerotic Cardiovascular Disease and Heart Failure with Influenza Vaccination
- 21 October 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Atherosclerosis Reports
- Vol. 23 (12), 1-10
- https://doi.org/10.1007/s11883-021-00973-w
Abstract
Purpose of Review The interplay between viral respiratory infections and cardiovascular disease has been most comprehensively researched using seasonal and pandemic influenza viruses as case studies. Here, we summarize the latest international observational research and clinical trials that examined the association between influenza, influenza vaccines, and cardiovascular disease, while contextualizing their findings within those of landmark studies. Recent Findings Most recent observational literature found that one in eight adults hospitalized with laboratory-confirmed influenza infection experienced an acute cardiovascular event. The latest meta-analysis of the cardioprotective effects of influenza vaccine found a 25% reduced risk of all-cause death. There are four large cardiovascular outcome trials assessing the cardioprotective effects of different influenza vaccine strategies. Among these, the INVESTED study showed there is no significant difference between the high-dose trivalent and standard-dose quadrivalent influenza vaccines in reducing all-cause mortality or cardiopulmonary hospitalizations in a high-risk patient group with pre-existing cardiovascular disease. Summary Persons with cardiovascular disease represent a high priority group for viral vaccines; hence, using robust evidence to increase vaccine confidence among patients and practitioners is integral as we prepare for a possible influenza resurgence in the coming years.This publication has 84 references indexed in Scilit:
- Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk PatientsJAMA, 2013
- Circulating Influenza Virus, Climatic Factors, and Acute Myocardial Infarction: A Time Series Study in England and Wales and Hong KongThe Journal of Infectious Diseases, 2011
- Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registryBMJ, 2010
- Meta-analysis: β-Blocker Dose, Heart Rate Reduction, and Death in Patients With Heart FailureAnnals of Internal Medicine, 2009
- Decreased Immune Responses to Influenza Vaccination in Patients With Heart FailureJournal of Cardiac Failure, 2009
- Air Temperature and Inflammatory Responses in Myocardial Infarction SurvivorsEpidemiology, 2008
- Risk of Myocardial Infarction and Stroke after Acute Infection or VaccinationThe New England Journal of Medicine, 2004
- Influenza-Associated Hospitalizations in the United StatesJAMA, 2004
- Mortality Associated With Influenza and Respiratory Syncytial Virus in the United StatesJAMA, 2003
- Excess Mortality from Causes Other than Influenza and Pneumonia during Influenza EpidemicsPublic Health Reports (1896-1970), 1932