The present study was carried out to determine the haematological and serum biochemical profiles of Clarias gariepinus juveniles fed commercial and farm-made feeds and reared in intermediate bulk containers (IBC) tanks. Nine hundred juveniles (15.15±3.48g; 128.37± 9.67mm) were stocked in 09 IBC tanks (1m3) at a density of 100 fish/tank in triplicate and fed with imported extruded (Le), locally pelleted (Lpe) and locally extruded (Lex) feeds thrice a day to satiation for 16 weeks. At the end of the experiment, blood samples were collected from 10 fish/ dietary treatment to determine haematological and biochemical indices. Results revealed that Red Blood Cells Count, Packed Cell volume and Haemoglobin concentration were highest (p0.05) among the dietary treatments. As for serum biochemistry, Total Cholesterol and Glucose were highest (pC. gariepinus reared in plastic IBC tanks.