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Near-field electrospinning of a polymer/bioactive glass composite to fabricate 3D biomimetic structures

Krishna Kolan, Jie Li, Sonya Roberts, Julie A. Semon, Jonghyun Park, Delbert E. Day, Ming C. Leu
International Journal of Bioprinting , Volume 5; doi:10.18063/ijb.v5i1.163

Abstract: Bioactive glasses have recently gained attention in tissue engineering and three-dimensional (3D) bioprinting because of their ability to enhance angiogenesis. Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues. In this study, we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning (NFES). An overall controlled 3D scaffold with pores, containing random fibers, is created and aimed to provide superior cell proliferation. Highly angiogenic borate bioactive glass (13-93B3) in 20 wt.% is added to polycaprolactone (PCL) to fabricate scaffolds using the NFES technique. Scaffolds measuring 5 mm × 5 mm × 0.2 mm3 in overall dimensions were seeded with human adipose-derived mesenchymal stem cells to investigate the cell viability. The cell viability on PCL and PCL+glass scaffolds fabricated using NFES technique and 3D printing is compared and discussed. The results indicated higher cell proliferation on 3D biomimetic scaffolds fabricated by NFES technique
Keywords: scaffolds / Viability / tissues / Structures / PCL / Nfes / fabricate

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